Khloé Kardashian opened up about the first time her estranged husband Lamar Odom met her former stepfather Caitlyn Jenner after her transition from Bruce. In a sneak peek for this week's episode of her hit late night FYI series "Kocktails with Khloé," the "Keeping Up with the Kardashians" star reveals details about their introduction during a sit-down conversation at the table in her kitchen.

Kardashian welcomes reality TV star and former Playboy model Kendra Wilkinson, R&B singer Trey Songz, "Awkward" star Jillian Rose Reed and comedian Pauly Shore as guests for the Wednesday, March 30, episode. Over cocktails, she explains that Odom did not meet Jenner until months after Jenner's transition and Odom's near-fatal drug overdose last year. She attempts to discuss how she handled introducing Jenner to Odom in his already fragile state, but she can barely get a word in without Shore interrupting her.

"Not to bring, like, Lamar into this, but Lamar first met..." Kardashian says in the clip.

"He got a sex change too?" Shore interrupts, laughing.

"No, actually, he didn't. He's good," Kardashian responds. "But when he had his accident and he was in the hospital, Caitlyn was like, 'I want to come and see Lamar to say...'"

"You don't think Bruce would have?" Shore interrupts again. "I'm just being straight, I'm being straight."

An awkward silence follows until Kardashian is ready to continue with her anecdote.

"Lamar did not know about Caitlyn at that time," Kardashian continues and her guests react with shock. "First of all, let me speak. So Lamar was in a coma, and Lamar was in the hospital for four months, and I kept Lamar very sheltered. During that time was when Caitlyn was transitioning, but also prior to Lamar's accident, Lamar was not in the best state. Or I wasn't there to see him, but I can't guarantee you he was watching television. I also know the state he was in and he wasn't healthy, and I don't think he was sitting, lying in bed relaxing and watching TV."

"So when Caitlyn wanted to come and visit Lamar for the first time was in the hospital," Kardashian continues. "I wanted to respect Caitlyn being Caitlyn but I also was like..."

"This is why you guys have the No. 1 show," Shore says, and Kardashian laughs it off.

Watch the full clip below and be sure to catch this week's episode of "Kocktails with Khloé" airing Wednesday at 10 p.m. on FYI.