The latest case was from the Philippines, where a 45-year-old woman was tested positive for Zika virus. The country's health department said this was the first confirmed transmission in the area.
Health officials pointed out that the case was most likely due to local transmission since the carrier was no history of travel to any affected country in the past two weeks.
On Sunday, Malaysian health officials reported of the two patients who were tested positive for Zika infections.
The first reported case was a 65-year-old woman living near Kuala Lumpur who possibly contracted the virus during a visit to Singapore. The second case was a 61-year-old man in Kota Kinabalu.
"The confirmation of the second case of Zika in Kota Kinabalu suggests that the virus is already present within our communities," according to Malaysian Health Minister Subramaniam Sathasivam.
In Singapore, the number of people suffering from the deadly Zika virus increased to 242. Singapore's high population density, coupled by year-round humid weather conditions, makes it an ideal place for Zika mosquitoes to thrive.
Following these reports, Thailand has speed up its campaign against Zika through the eradication of possible breeding sources of carrier mosquitoes.
With several of Asia's megacities reaching daytime populations beyond 10 million, many of them are vulnerable to the virus' onslaught.
CNN reported that around 2.6 billion people in Asia and Africa could contract Zika.
