This amid circulating rumors that Amber is reportedly dating billionaire Elon Musk, who has tried to ask her out for years.
In an interview with Daily Beast, Manson said Amber "crucified" Johnny in the press.
"Johnny is one of the nicest people that I know-to the extent where it's almost heartbreaking how kind he is to his friends, and everyone around him. I know that he was completely crucified-unjustly," Manson said.
"I would stand by him on anything. As my friend, I know that he's handling it the best he can and he's a great dad, too. It fills me with joy to see his kids grow up and be so smart, and so hilarious," she added.
Manson was a godparent to Depp's daughter Lily-Rose, who was born in 1999 from his marriage to Vanessa Paradis.
Depp, an avid guitarist was also seen performing with Manson on stage. Manson and Depp are very close friends.
Depp and Heard has reached $7million out-of-court divorce settlement few weeks ago according to E! News.
Heard said she would donate her divorce settlement money to charity, sparking a drama between her and Depp as she gained more sympathy from the press.
Previously, Heard revealed that Depp verbally and physically abused her.
Her statement was denied by Manson saying, "It's hard to say when you talk about your friends. Of course I think that all of it was bulls--t, and I think that he is a great person. I wouldn't agree with any of it if someone were to put me on the stand and ask me what I know, or what I've witnessed."
Meanwhile, Heard is reportedly dating billionaire Elon Musk, founder of Tesla.
Prior to her divorce, according to Hollywood Reporter, Musk and Heard were spotted together.
