Comedy legend Harold Ramis, best known for his role in the hit "Ghostbusters" films, has died at the age of 69 early Monday, Yahoo Movies reported.
Ramis, whose irrepressible comic chops shone through as an actor ("Ghostbusters," "Stripes") and director ("Groundhog Day," "National Lampoon's Vacation," "Caddyshack"), died from complications of autoimmune inflammatory vasculitis, which is a rare disease that involves swelling of the blood vessels, according to his wife Erica Mann.
A Chicago native, Ramis moved back to his hometown with his family in 1996. "I feel like I represent the city in a certain way," he said a few years later, according to Yahoo Movies.
Following an infection that ultimately caused his rare condition, Ramis began having health problems in 2010.
"A true comedy Renaissance man, Ramis was a towering influence in Hollywood with a streaks of hits that stretched from the 1978 classic 'Animal House,' which he wrote, to 1984's blockbuster 'Ghostbusters,' which he wrote and starred, up to the 1999 hit 'Analyze This,' which, like the 2002 follow-up 'Analyze That,' he wrote and directed," Yahoo Movies reported.
"Deeply saddened to hear of the passing of my brilliant, gifted, funny friend, co-writer/performer and teacher Harold Ramis," his "Ghostbusters" co-star Dan Aykroyd wrote. "Ghostbusters" director Ivan Reitman also acknowledged the passing of "the most agile mind I've ever witnessed."
Billy Crystal, who starred in Ramis' "Analyze" movies, called him "A brilliant, funny, actor and director. A wonderful husband and dad. Big loss to us all."
Dating back to his college years at Washington University in St. Louis, Ramis used to write parodies for the stage.
"After graduating, he moved back to Chicago. And by the early '70s he was sharing the stage at Second City with John Belushi and other fellow collaborators, also launching skit comedy show 'SCTV.' In 1974, Ramis, Belushi, and Bill Murray moved to New York with other performers from the famed Chicago comedy troupe to do 'The National Lampoon Radio Hour,'" Yahoo Movies reported.
When Ramis wrote the 1978 frat-house comedy "National Lampoon's Animal House," starring Belushi, he found his big-screen break. From there, Ramis penned 1979's "Meatballs," starring his other creative collaborator, Bill Murray - their fruitful team-ups included "Caddyshack," "Stripes," "Ghostbusters," and "Groundhog Day."
"Ramis's signature style, mixing both ludicrous and insightful humor, has had a lasting influence," according to Yahoo Movies. "'Meet the Parents' director Jay Roach has cited Ramis's impact on him, as have Adam Sandler, and Peter and Bobby Farrelly ('Dumb and Dumber,' 'There's Something About Mary'), along with Judd Apatow, who cast Ramis in memorable roles in 'Knocked Up' and 'Walk Hard: The Dewey Cox Story.'"
Ramis leaves behind his wife, Erica Mann, and three children, Yahoo Movies reported.
