Slash will receive the Les Paul Award at the 30th annual Technical Excellence and Creativity Awards during the National Association of Music Merchants Show in Anaheim on Saturday, Jan. 24.
Comedian Sinbad will host the evening event.
The NAMM TEC Awards honor individuals and companies for outstanding achievement in professional audio technology and production.
Slash, who established a solo career in 2008, is known as former lead guitarist for Guns N' Roses and founded the supergroup Velvet Revolver. His current album is called "World On Fire."
Slash, whose real name is Saul Hudson, has amassed album sales of more than 100 million copies.
He has won a Grammy and has seven Grammy nominations. He was inducted into the Rock and Roll Hall of Fame with Guns N' Roses in 2012.
Time magazine named Slash second, behind only Jimi Hendrix, on its Ten Best Electric Guitar Players of All-Time list. His famous guitar solos in songs including "November Rain" and "Sweet Child O' Mine" are adored by rock fans worldwide.
The Les Paul Award, named for the musician and inventor, honors individuals or institutions that have set the highest standards of excellence in the creative application of audio and music technology. Previous winners include Paul McCartney, Brian Wilson, Stevie Wonder, Neil Young and Peter Gabriel. Last year's recipient was Todd Rundgren.